Attention lapses due to sleep deprivation due to flushing fluid from brain
214 comments
·October 31, 2025earless1
layer8
Luckily it doesn’t clear all unreferenced memory, though.
blauditore
Fun fact: Suppressed/hidden/lost memories due to trauma that appear to re-surface through therapy are not a real thing, as previously thought (and still by some psychotherapists). Nowadays it's understood by psychology that any memories "re-surfacing" in therapy are in fact newly created, although the patient themselves cannot tell the difference. Allegedly, whole accusations of childhood abuse may have been created out of thin air, without the victim realizing.
https://en.wikipedia.org/wiki/Recovered-memory_therapy (see research section)
pcthrowaway
Sure it's a real thing for memories to surface that were previously buried. It's happened to me.
If it happens in therapy, that doesn't mean the memories are "implanted". And not all memories lack the ability to validate them... for example, if you've forgotten someone's name, then remember it later, you can call out to them by their name to confirm that you've correctly remembered it.
Memories tumble around in the brain all the time, not all memories are easy to access, but that doesn't mean they're inaccessible.
The point that memories can also be implanted or fabricated during therapy is absolutely an important one, but dismissing the possibility for memories to resurface (and conflating any situation where this might happen with a specific type of discredited therapy) is needlessly reductive.
DiscourseFan
There are two types of repression, however. The notion that primarily repressed memories--say, those of being breastfed, of being potty trained--could ever resurface is bogus of course. But it is that original violence, first of being cared for, and then having that care taken away and even, in many cases, transforming into authoritarian violence in order to be socialized properly, that precipitates all other "secondary" repressions like Freudian slips, even screen memories or rationalizations. No, most people traumatized past the age of say, 5, won't readily forget it. But perhaps they will have a way of reconciling with that trauma in an unhealthy or not fully conscious manner (consider self-harming, or drug abuse, making up a narrative in order to stay with a partner who violently abuses them). And they will not readily connect their traumatic experiences with their unhealthy coping mechanisms. And we could say that the connection between unconscious behaviors and trauma, when revealed, could be considered a "re-surfacing." Even if I can't remember being breastfed, I know that I find the warm embrace of another's arm's comforting and soothing, and this perhaps relates to my original state of relaxation as a child in my mother's arms, for instance.
dbspin
The problem is not that memories can't be repressed. There's plenty of research demonstrating repression does exist as a defence mechanism. The problem is that even highly evocative memories can also relatively easily be falsified, or modified through elicitation and reframing. Since there's no neurological stenographer, there is no mechanism even in principle to identify the difference between the two. With potential consequences like the satanic panic of recovered and elicited memories of sexual abuse. That's what Elizabeth Loftus and others have shown, and shown so thoroughly that eye witness testimony should never be trusted.
layman51
This idea of unconscious memories perhaps being a type of fantasy is also discussed in this article too:
layer8
People can remember things that hadn’t re-entered their mind for decades. It certainly happened to me a number of times (completely trauma-unrelated and not actively elicited).
elmomle
The statement "there is evidence of black swans" does not justify the conclusion "every swan is black".
agumonkey
I beg to differ, or at least I'd need clarification, some people experience traumatic visions from what is assumed repressed memories (with or without therapy)
It might be something that one might not understand if he/she doesn't live through it I guess
bollocks9
What about Dr. Jim Tucker’s two child psych cases, James Leininger and Ryan Hammons?
One remembered memories of a WWII pilot named James Huston Jr. and the other a deceased Hollywood agent named Marty Martyn.
Putting aside the reincarnation hypothesis for the moment, do you think the kids invented the details and coincidentally happened to match to a real person or were they fully coached? Maybe they didn’t get enough sleep or got too much sleep?
bigbuppo
I forgot what I was going to type, but I didn't get enough sleep last night.
DenisM
Cleanup is an LRU process.
Once a memory lapses you have to relearn from life experience (or not at all).
thaumasiotes
No, a lapsed memory can be provoked. It doesn't have to be relearned. It is "lapsed" because the organizational path to it within your brain has been lost, like a book in a library that has been left out of the card catalog, but just like the book, if you happen to find it anyway, it will be there.
Compare, from https://evolutionistx.wordpress.com/2016/12/16/anthropology-... :
> at the first news of English ships in the area, Buckley rushed to the spot. He attempted to make contact, but couldn’t swim out to the ship and couldn’t convince the ship to send a boat to him (Buckley had, at this point, forgotten how to speak English.) Buckley was again heartbroken until another ship showed up, and he found the English colonists and tried to approach them:
> “Presently some of the natives saw me, and turning round, pointed me out to one of the white people; and seeing they had done so, I walked away from the well, up to their place, and seated myself there, having my spears and other war and hunting implements between my legs. The white men could not make me out–my half-cast colour, and extraordinary height and figure [Buckley was around 6’5” or taller,]–dressed, or rather undressed, as I was–completely confounding them as to my real character. At length one of them came up and asked me some questions, which I could not understand; but when he offered me bread–calling it by its name–a cloud appeared to pass from over my brain, and I soon repeated that, and other English words after him. …
> “Word by word I began to comprehend what they said, and soon understood, as if by instinct, that they intended to remain in the country; that they had seen several of the native chiefs, with whom–as they said–they had exchanged all sorts of things for land; but that I knew could not have been
I submit that it takes more than a day to learn English if you don't already know it.
Once I was in a Toys-R-Us and noticed a cover image among the bottom-of-the-barrel DVD display which caused me to put what I was doing on hold for several minutes while I stared at the DVD. I bought it, and it turned out to be a movie I had watched many times when I was very young, but that information hadn't been accessible to me.
jyounker
Are you sure about that?
ghurtado
I realize you're making a joke, but there is no such thing as "unreferenced memories", as in, something that is no longer in use and has been removed from the brain.
Every memory your brain has ever produced is still there, even if most are beyond conscious access. Memories quite literally become a permanent part of you.
A lot of people mistakenly think of human memory as a sort of hard drive with limited capacity, with files being deleted to make room for new ones. It's very much not like that.
pdonis
If you are implying that human memory has infinite capacity, that's not possible. The human brain is a finite, physical thing. It can't store an infinite amount of data.
If you just mean that human memory has a finite capacity that's much larger than anyone has come close to reaching by storing the memories of a normal human lifetime, that might make sense.
Do you have any references for your statements about memory? I'm not familiar with whatever science there is in this area.
vanviegen
Bullocks. Memories fade. Or do you really believe that 'subconsciously' I still know what I had for dinner today exactly 30 years ago?
The way I understand it, it's just that, unlike on disk, the deletion process is not binary. Weak connections that are not revisited regularly gradually become weaker, until they're undistinguishable from noise (false memories).
mym1990
Knowing almost nothing about memory and the brain, I don't know if I agree with "Every memory your brain has ever produced is still there".
Memories seem to be constructed by a group of neurons together, and it seems clear that neurodegeneration is a thing, whether by trauma or due to aging. When pathways degenerate, maybe you have a partial memory that you brain can help fill the gaps with(and often incorrectly), but that does not make it the original memory.
lux_sprwhk
I had this experience at Big Bend State park that makes me think they are. I didn't bring enough water and camped in the primitive area. At night, I was dehydrated pretty bad. When I finally got a little sleep (it was tough to say the least), I had this vivid dream where I put a pebble in my mouth and started sucking on it to make saliva. Then I woke up for real, and I knew it because there was a lot of wind IRL, that wasn't in the dream. So I took out a coin from my back, put it in my mouth to make saliva, and got a little bit of relief. Enough for a couple hours until it was dawn, and had enough light to hike down to the restroom area.
I don't know where I got this trick. Likely some survival show or some novel. But I don't have any background in survival, otherwise, I would have brought a lot more water.
So my brain knew there was a memory that could help and made up a dream about it is my theory.
Zenul_Abidin
Is Sun Microsystems in the room with us?
HEmanZ
I hope that the actual medical field starts taking note of this.
My wife still has to work 24 hour shifts with no sleep, performing emergency surgeries no matter how long it has been since she slept. During residency only a few years ago she and her co-residents were almost weekly required to do 36 hour shifts (on top of their regular 16 hours per day, 5 day per week schedule) and once even a 48 hour shift when the hospital was short staffed.
Of course I’m sure they won’t. No one cares if doctors are over worked.
lordnacho
I've never understood those long shifts. Unless a shift just means you are there but sleeping, what is the reason for allowing it? We don't let truck drivers do 24h shifts, why do doctors the world over seem to do this?
munificent
My understanding is that the research shows that the harm to patient care from information loss during doctor shift turnover is worse than the harm from fatigued doctors.
Yes, a tired doctor sucks. But a tired doctor who already has the patient's state loaded into their head may still be better than doctor who is completely fresh in both senses.
It's a hard problem.
K0HAX
Instead of 1 doctor covering a 24 hour shift, why not pair them and overlap?
12:00am - 6:00am: Doctor 1 and Doctor 4 are doing everything together.
6:00am - 12:00pm: Doctor 1 and Doctor 2 are doing everything together.
12:00pm - 6:00pm: Doctor 2 and Doctor 3 are doing everything together.
6:00pm - 12:00am: Doctor 3 and Doctor 4 are doing everything together.
This way, all 4 doctors only do 12 hour shifts, and the patient's state is maintained continuously through all 24 hours.
arcticfox
> Yes, a tired doctor sucks. But a tired doctor who already has the patient's state loaded into their head may still be better than doctor who is completely fresh in both senses.
AI fixes this. Imagine the boot time of loading a patient's state from dozens of labs and files vs. a summary that gets you to exactly what they're going to end up remembering anyways. And if a doctor finds something interesting that the AI doesn't flag, they should be flagging it in the chart for the next doctor anyways.
Fire-Dragon-DoL
What about the harm to the doctor themselves+the harm to the patient? Would the sum of both be worse?
harperlee
That only works if the mean stay in the hospital (or at least the critical care period) is several hours but also way below 24h…
thaumasiotes
> My understanding is that the research shows that the harm to patient care from information loss during doctor shift turnover is worse than the harm from fatigued doctors.
This would not appear to apply to emergency surgeries. They aren't done by doctors who are familiar with the patient anyway. (Neither are non-emergency surgeries. Surgeries are done by doctors who do that kind of surgery. Familiarity with the patient is useful in deciding what surgery should be done, but not in doing the surgery.)
renewiltord
The European Working Time Directive has requirements for rest, etc. Either Europeans have much better hand-off procedures, they don't know how to comply with the rules they make, or they're fucking idiots who are going to kill people due to information loss during shift turnover. It was proposed decades ago. I wonder what compliance is like in Germany, etc.
null
null
cma
The AMA works to prevent importing doctors from other countries, largely to maintain wages, but we don't have enough doctors.
Doctors boards and AGME (partly governed by AMA, but there is some amount of public representation) control residency admissions and board certification. We don't necessarily want low admissions standards, but there is a lot potential conflict of interest in constraining supply.
Some states, I think I read Florida recently, have started pushing back to allow in foreign doctors.
random3
I think both doctors and patients would want a different system for both doctors and patients. Having seen a poor performing medical system, and comparing it with the US medical system, all I can say it's that the US one doesn't seem designed to optimize health and well being of patients and, based on reading several articles representing doctors opinions, neither doctors'.
I do think it's maximially optimized to extract revenue. That can sometimes be good (e.g. good access to healthcare) but often times it's not great.
Given healthcare, along with education should be a national priority, both should be heavily "configured" to serve peoples' goals first and any financial goal should be secondary (although arguably useful).
I suspect the current shareholder structures from hedge funds are (intentionally or not) driving things in the wrong direction wrt to public health goals. This is article from a few days ago is also interesting https://news.ycombinator.com/item?id=45680695
ineedaj0b
her at her worst is better than 90% of people at their best.
if you get through and into a good med school -match into surgery- you are Peak in a way very few are.
I don’t see this changing unless they reduce the requirements for med school; if they let anyone in who wants in and force that group to work 30hr shifts - you’ll get enough bad outcomes the system will change.
There was a study, I believe on nurses and shift durations. The study found the nurses were happier with shorter shifts - but the patients did worse. Patients come first.
I could see a group of Doctors loudly proclaiming love for Donald Trump (and mentioning very much how great he is) and pleading the case for a change and something happening. He is an interesting president.
I would be interested in hearing a european drs perspective, I heard they work shorter shifts (but no EU dr I met has confirmed, it’s like meeting a unicorn)
lostlogin
> her at her worst is better than 90% of people at their best.
A fraction of a fraction of a percentage of people are good at surgery.
If I need someone cutting me, I’d prefer someone good, and that they were rested.
jdthedisciple
Allow me to be a bit blunt here:
Don't you, as presumably a SWE in the US, make a sh!tton of money?
Howcome your wife still is forced into such detrimental working conditions?
switchbak
This is the nature of the medical system in North America, and some other advanced nations. Also, you're not just being blunt, you're being both ignorant and arrogant.
jdthedisciple
If OP feels the same way, I offer my heartfelt apologies.
I don't think what I said would come across this negatively in person though, but okay..
astrange
A surgeon is going to make more than an SWE. Also, surgeons are famously unhappy with anyone questioning any of their decisions.
lostlogin
It’s an interesting paradox.
Imagine doing your best to help someone and they die as a direct result.
Then you get to go to work and deal with the next case.
Or the patient has life changing, negative outcomes. Damn, that bad. Next case.
That takes a pretty unusual character type. We can expect some extreme behaviour.
cestith
Who said she was forced, and why the personal attack?
jdthedisciple
> still has to work 24 hour shifts with no sleep
Reads like being more or less forced to me, it doesn't to you?
> and why the personal attack?
Not at all my intention! It's a genuine question, which I would ask myself too were I in OP's shoes
codethief
> The scientists found that during these lapses, a wave of cerebrospinal fluid (CSF) flows out of the brain
> Lewis and colleagues showed that CSF flow during sleep follows a rhythmic pattern in and out of the brain
> Most significantly, they found a flux of CSF out of the brain just as those lapses occurred. After each lapse, CSF flowed back into the brain.
I can't believe the authors of the article didn't address one of the most obvious questions: Where does the CSF flow to and where does it flow back from? It's not like there are pipes leading out of the brain, or the CSF will just leave my brain through my ears or anything, will it?¹ What happens with the waste products? (¹ Though it would be kinda funny if this was where snot comes from.)
EDIT: Wikipedia's got the answer:
> Clearing waste: CSF allows for the removal of waste products from the brain,[3] and is critical in the brain's lymphatic system, called the glymphatic system. Metabolic waste products diffuse rapidly into CSF and are removed into the bloodstream as CSF is absorbed. When this goes awry, CSF can become toxic […]
dragonwriter
> It's not like there are pipes leading out of the brain
There are, in fact, “pipes” leading out of the brain. Cerebrospinal fluid is (and this is probably somewhat oversimplified) produced from material in the bloodstream in the ventricles in the brain, flows through the system of ventricles and then out of the brain into the subarachnoid space around the brain and spinal cord, and is then reabsorbed into the bloodstream.
cvoss
And some people literally need an actual pipe implanted to assist with CSF drainage.
https://www.mayoclinic.org/tests-procedures/brain-shunt/abou...
gcanyon
What I want to know is: can we trigger these flushes? My grandfather died of/with Alzheimer’s, and I’d prefer not to follow in his footsteps. If we determine that these flushes are key to good brain health, and there were a way either through a pill or even a treatment to up the frequency of these flushes, that would be awesome.
HPsquared
Choosing to sleep more, I guess.
handfuloflight
I can feel when this fluid hasn't properly flushed.
binary132
What I’m picking up here is that if I can just get an automated CSF circulator installed I won’t need to sleep or get distracted when I’m tired. That was the point of this article, right?
rtaylorgarlock
Long live healthy sleep for brain health, and thank goodness light exercise helps this same glymphatic system.
0xbadcafebee
So... can we trigger it manually? I'd love to be able to lay down and press the 'flush brain' button.
vrx-meta
Research on NDSR, I have been using this for days I had to wake up without proper rest.
If you have 15m, search this on YT for a guided practice and test it yourself.
GavinMcG
NSDR, rather—Non-Sleep Deep Rest.
BobaFloutist
I believe you were referring to NSDR (Non-Sleep Deep Rest)?
niwtsol
Kind of related, but there is a concept of polyphasic sleep - where you sleep for small increments throughout the day (like 30 minutes every 3 hours). I did it for a bit at a startup thinking we were "hacking sleep" and "getting more productive hours out of every day!" - It takes awhile to transition to it, but once there, your scheduled "sleeps" are insane, 15 minutes, feel like straight to REM. The main problem was if you missed on schedule sleep you were a zombie.
tetha
Yeah, when I was looking into the plausibility and function of polyphasic sleep, I stumbled across studies from the US Airforce. Their conclusion was similar: In a controlled enviroment, it can be spectacular and work really, really well.
However, it is very, very fragile to any kind of interruption, so they stopped looking into it.
cestith
When I worked an overnight shift and lived alone, I got into a pattern of 2 to 3 hours a go three times a day. These were after work, halfway or so through my personal time, and before work. I used these separate times in between sleeps for work, almost exclusively for chores, and a dedicated slot for hobbies. I started each one refreshed, which was great. It doesn’t necessarily work so well when aligning your life with a partner.
pbhjpbhj
Searching back, as I recall a video that was supposed to cause [increased] CSF flow, I did find this - https://news.ycombinator.com/item?id=34764730 about suggestions some learning difficulties might be due to interrupted CSF fluid flow.
The video (?) was related to clearing of plaques from the brain with a view to mitigating Alzheimer's effects.
It was not the NSDR (Non-Sleep Deep Rest) videos a sibling commenter posted.
g-b-r
If you're very tired you should be able to fall asleep, or at least doze off, whenever you let yourself go.
It seems likely that you'll get those flushes right after falling asleep, so a nap of a few minutes could help a lot.
In my experience, after a night without sleep even a 30 seconds nap reinvigorates you significantly.
ferguess_k
I wonder if a 30-min nap improves the situation. But I need to tell the brain to hold the flushing until the nap.
JKCalhoun
Anecdotally, it seems to. I have laid down and closed my eyes even for a short while. And believe that I have even had a "flushing" sensation, that feels like a mental fog being lifted (or "drained", I guess).
I pop up 5 minutes later and feel completely refreshed.
256_
I do something similar, although there's an added peculiarity when I do it. I lie down for 5 minutes and wake up 9 hours later.
assimpleaspossi
Agree though it's 10 minutes for me.
When I owned some property out in the country, it was a 2 1/2 hour car trip to get there. Sometimes I just couldn't finish the drive home but pulling over to the side of the road for a 10-minute nap made me feel fully refreshed.
ferguess_k
I had the same experience. The only trick is to keep it short, like 5-10 minutes. Any longer and the nap may bring negative impacts.
nullstyle
Fwiw, i have the opposite experience of napping. Napping adds to mental fog for me especially for the hour immediately after napping. Its not until several hours later that i actually experience any loss of mental fog or increase in clarity.
g-b-r
It probably depends on how much sleep you're lacking, and how long the nap is.
My experience after sleeplessness nights is that even few seconds help significantly, especially when you're almost unable to function anymore.
If the nap lasts longer than 30 minutes, though, you have a good chance of feeling groggy afterwards.
rtaylorgarlock
There's controversy over exact mechanisms involved in glymphatic function, so suffice it to say that allegedly even just NSDR / yoga nidra will engage a rest deep enough for glymphatic function to engage/improve
DenisM
I was disappointed the article didn’t mention that. Can you give me some pointers. I will use Google but HN curated content is often a better starting point. :)
gwbas1c
> I wonder if a 30-min nap improves the situation.
I pretty much wait until I feel drowsy, and then take a 15-30 minute nap
paglaghoda
Rest in peace to all the college dudes covering the whole syllabus within 24 hours of the exam
wslh
It is always great to follow the instructions from a psychiatrist [1].
[1] https://thelastpsychiatrist.com/2007/08/how_to_take_ritalin_...
thesmtsolver
This is just outdated, bad and dangerous advice that a ton of recent research invalidates.
1. Ritalin, and other stimulants are not cognition enhancing for non-ADHD adults and may in fact do the opposite.
https://www.cam.ac.uk/research/news/smart-drugs-can-decrease...
2. > Because the doctor will rigorously apply artificial and unreliable diagnostic categories backed up by invalid and arbitrary screens and queries to make a diagnosis. So after this completely subjective and near useless evaluation is completed, your doctor should be able to exercise prudent clinical judgment to decide if Ritalin could be of benefit.
What else can you do for psychiatric conditions? We don't have a magic ADHD-o-meter but know that it statistically impacts lifespan, health, etc. Even for more objective measures like blood glucose, BP, BMI, clinical interventions are based on discrete thresholds that don't exist in nature.
mctt
[flagged]
hombre_fatal
Everyone has an LLM tool a couple clicks away if they want it, so I don't think we need this kind of contribution. And this summary is too much of a summary to be useful anyways.
johnisgood
There is much more to it.
There is such a thing as state-dependent memory or context-dependent memory: recall is better when the environmental context (e.g. location, lighting, smells) matches the context of learning.
If you study while on Adderall, which alters your neurochemical state (increasing dopamine and norepinephrine activity), you may recall that material more effectively when you are in the same neurochemical state, that is, also on Adderall.
Similarly, if someone learns something while sober, they will generally recall it better when sober again, rather than under the influence of a drug.
It is the phenomenon where memory recall is improved when the internal physiological or psychological state matches that during learning.
fukka42
The comment above reduces the interesting article to a lacking one sentence summary. It is indicative of someone who is both too lazy to read something for themselves and for some reason thinks it is a good idea to admit this publicly.
znpy
Not a college dude, but i used to work on shits (including night shifts) and adjusting to and from a five-nights (23:30-07:30) shift isn’t that pleasant either.
nfriedly
I think you meant to say "...I used to work on shifts..."
That, or maybe try a laxative.
(Man, if ever there was a time I wanted emoji support on HN, this is it!)
assimpleaspossi
Maybe unrelated but, years ago, I had a job that had me criss-crossing the country by plane Monday through Friday and sometimes Saturday. So my sleep and the time zones and hotels could sometimes mess with me.
One day, I went to a grocery store and mid-turn onto another street, I forgot what city I was in. Worse, I was half a mile from my apartment in my home town.
hollerith
How long did it take you to orient or to get home (whichever one happened first)?
heywoods
This reminds me of delirium tremens a bit. Same compensatory mechanism, different sleep process - or at least that's the pattern I'm seeing.
The MIT study shows CSF waves—normally a sleep-only process that flushes metabolic waste—intruding into wakefulness when you're sleep-deprived. Your brain is apparently so desperate for the cleanup that it forces the process to happen anyway. Cost: attention lapses.
From what I've read, delirium tremens during alcohol withdrawal seems to follow a similar pattern, except it's REM sleep intruding into waking consciousness instead of CSF flushing.
[Polysomnographic studies from the 1960s-80s](https://pubmed.ncbi.nlm.nih.gov/7318677/) documented this. Patients in alcohol withdrawal exhibit what researchers call ["Stage 1-REM"](https://www.sciencedirect.com/topics/neuroscience/delirium-t...)—a hybrid state where wakefulness and REM sleep characteristics get mixed together. Right before full-blown DTs, [some patients hit 100% Stage 1-REM](https://link.springer.com/chapter/10.1007/978-1-4757-0632-1_...). The hallucinations appear to be [literally enacted dreams](https://www.sciencedirect.com/science/article/abs/pii/S01651...) occurring while technically awake. The sleep-wake boundary just completely breaks down.
What strikes me is the system-level similarity here. Sleep normally maintains clean states: you're either awake (alert, reality-testing intact, no CSF flushing) or asleep (offline, dreams permitted, maintenance running). But when the system gets stressed enough—whether through sleep deprivation or the neurochemical chaos of alcohol withdrawal—it seems to start making desperate tradeoffs.
The brain apparently needs certain processes to run. Period. Total no-brainer! CSF flushing can't wait indefinitely. Neither can REM sleep, which serves its own critical functions. So when normal sleep architecture fails, the system appears to force these processes anyway, even though the conditions are completely wrong for them.
Maybe that's why the costs are so specific. CSF intrusion during wakefulness costs you attention. REM intrusion costs you reality testing, because REM is the state where your brain accepts impossible narratives without question. Same compensatory mechanism, different critical process forced into the wrong state.
What I find interesting is how the brain knows what lever it needs to pull and how it pulls it. Sleep deprivation forces waste removal. REM deprivation forces wakeful dream states; which might be a side effect not the actual goal. The brain seems to know what maintenance is overdue and attempts the repair, consequences be damned.
So biological garbage collection pauses then? skip sleep, and the brain tries to run gc cycles during runtime. Causing attention and performance latency spikes. Evolution wrote the original JVM.