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New stem cell model sheds light on human amniotic sac development

Metacelsus

Pretty cool that they were able to get these to grow to 1.5 cm without collapsing. It's also interesting to note that a lot of the early regulatory factors involved in amnion formation (BMP signaling targets, specifically) overlap with primordial germ cell regulators. In fact germ cells can be co-specified with amnion in another stem cell system (https://pubmed.ncbi.nlm.nih.gov/37426764/)

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