Toothpaste made with keratin may protect and repair damaged teeth: study
178 comments
·August 16, 2025buybackoff
safety1st
I don't know what this new hairpaste does, but Novamin promotes re-enamelization of teeth, which is where mineral ions like calcium bond themselves to the tooth and fill in small pits and fissures. It's not regrowing actual enamel, it's probably not going to fill in any pits you can see with the naked eye, but it's a real and beneficial effect. Actually any fluoride toothpaste also does this, but Novamin may be a bit more effective at it.
buybackoff
I had an impression that Novamin creates an artificial layer as strong as natural enamel, and fills tiny holes that are responsible for high sensitivity with this material that crystallizes with water contact. Then normal Ca+F mineralisation is orthogonal. Novamin itself contains Ca, can it really migrate from the crystals into the tooth tissue?
alyx
Never heard of Novamin but doesn't look promising?
https://pmc.ncbi.nlm.nih.gov/articles/PMC7068624/
Conclusion Review shows that Novamin has significantly less clinical evidence to prove its effectiveness as a remineralization agent in treating both carious and non-carious lesion. Hence, better designed clinical trials should be carried out in the future before definitive recommendations can be made.
buybackoff
Inetersting, the paper explain how remineralisation works and the role of F and fluoroapatite. This reminds me the recent Veritasium video about why Teflon is so strong - F chemical bonds are the strongest.
For Novamin alone, I've seen and understood the claims of sensitivity protection with hydroxyl-carbonate apatite (HCA). The paper explains it in 4.3. The layer is temporary and protects from acids, conserving the teeth tissue below.
But F is essential and my paste has it together with Novamin. It seems they may work well together. But the paper also explains that F works with saliva rich in minerals to repair the enamel. So if Novamin creates a strong layer, it may block access of F + saliva to enamel (my speculation, as in 4.2 they say "A clean tooth surface is required to access the mineral-deficient spot.").
So maybe a classical Ca+F paste is better overnight when no acid exposure is expected, but Novamin is nice in the morning before breakfast.
aspenmayer
> is nice in the morning before breakfast.
I typically brush after meals, not before, but however you do it is better than not doing so at all.
majkinetor
I use novamin but I can't feel a chemical reaction.
Have you noticed something more promising ? I am not sure, because I typically do not eat carbs.
buybackoff
I feel it on the spot that was sensitive to cold, and that was the reason I looked for something new. The paste is of room temperature, so that feeling must be not a fluke. No idea if it actually works, F+Ca used to be enough.
jbjbjbjb
The image with the cross section looks convincing. I don’t really know what I’m looking at.
upghost
> marketing leaves a bad taste in the mouth.
Hard to brush that one off!
[that was brilliant, you missed your calling. I am completely enamled :D]
bobajeff
>While fluoride toothpastes are currently used to slow this process, keratin-based treatments were found to stop it completely.
That's really great I hope to use this some day.
dotancohen
Sensodyne toothpaste has two lines: one that contains a mild painkiller (Rapid Relief) and one that [claims to] repair small cracks in teeth (Repair & Protect).
I use the latter. I do not know if it works, but I use it. I have never suffered from tooth pain before or after.
mackey
It depends on the country also. In the UK for example, Repair & Protect uses novamin but in the US it just uses stannous fluoride.
ben_w
Was thinking about oddities of language recently (happens a lot since moving to Germany), specifically how "toothpaste" isn't made from teeth and "tomato paste" isn't something you rub onto a tomato.
So anyway, should we be calling this "hairpaste for teeth", or "toothpaste from hair"?
mcswell
This semantic variability in the relation between the two nouns of a compound is pretty common in compound nouns: "Y made of X", like "tomato paste", "Y used (somehow) for X" (like "toothpaste", "paintbrush", "electrical outlet"--here an adjective, but still a lexicalized phrase), "Y in X" ("treehouse"), "Y for X" ("doghouse"), "Y containing X" ("paint can"), not to mention metaphorical uses, with some etymological relation between X and Y ("moon shot", "crapshoot", "greenhouse"), and so on. Not to mention multi-word compounds, like "greenhouse gas"--but I'm sure you've seen lots of those in Germany :).
Birch-san
“Windows Subsystem for Linux” is probably the most confusing example of this (an environment subsystem which provides a Linux userspace to a Windows NT kernel). more intuitive would be to call it a Linux Subsystem for Windows, but presumably for branding purposes they wanted Windows in front.
1718627440
That one isn't an example of this. It is actually a Windows Subsystem (at least WSL1) that exposes Linux syscalls, so is for Linux userspace programs. There is also the Windows Subsystem for Win32 and there used to be a Windows Subsystem for Unix.
Linux Subsystem would be completely wrong, because it is a Subsystem of Windows not of Linux.
nkrisc
“Toothpaste” is the commonly accepted English word (in most English dialects, as far as I’m aware) for that paste which we use to clean our teeth with a brush. So I expect we’ll call it “toothpaste” regardless of the exact chemical composition.
If keratin is the active ingredient, I would suspect the exact source doesn’t really matter.
swores
I agree that the source won't be a reason for not calling it toothpaste, but I wouldn't be surprised if it's not called toothpaste anyway - that's a term they're using now as it makes it easy for people to imagine what they're talking about, but dentists don't call every type of gel/stuff that they apply to teeth "toothpaste", and as this will be about targeting repair rather than daily cleaning I suspect it will get a new name.
nkrisc
I meant colloquially.
null
BobbyTables2
Indeed.
We expect olive oil to be made from real olives, but not baby oil…
Waterluvian
The coffee cake is a lie.
lazyasciiart
18 years in the USA and this still makes me sad. https://www.taste.com.au/recipes/jennys-coffee-cake/e2f028f1...
tacker2000
There was some joke where they showed a sign saying “Kinder Kebab, €2”
boothby
Thanks for this, I'll be calling it toothhairpaste regardless of what the marketing department comes up with.
SweetSoftPillow
Is Baby Oil made from...?
tchalla
Isn’t it Zahnpasta in German too?
ffsm8
Sometimes you need a (language) barrier to realize a inconsistency/detail which you'd never take notice of otherwise.
1718627440
Tomato paste is Tomatenmark, not Tomatenpaste though.
readthenotes1
I only clean my teeth with a dentifrice. I do not want to have to risk turning my teeth into paste!
sohkamyung
Open Access Paper: [ https://advanced.onlinelibrary.wiley.com/doi/10.1002/adhm.20... ]
CGMthrowaway
How does this compare with nano-hydroxyapatite, which is the current rage in toothpaste innovation and remineralization?
skylissue
nHA is prohibitively expensive to produce and the most effective process that produces the smallest particles is patent-protected by Sangi, and therefore many nHA toothpaste brands only contain a fraction of the concentration used to produce the effective results reported in academic studies (1-2% instead of 10%).
If keratin toothpastes can be produced more economically they could be a better option for mass adoption. For anyone who wants to try nHA toothpaste for remineralization, I can only recommend Sangi Apagard Royal toothpaste ($$$) but it does work quite well when used as directed.
NKosmatos
That’s very good news, but we’ll have to wait a little bit: >>> “keratin-based enamel regeneration could be made available to the public within the next two to three years.”
orliesaurus
Funny that the first picture on the website is a bald man, I guess he hasn't tested it himself?
dkiebd
Why do you think he ran out of hair?
jncfhnb
Perhaps he had hair before the harvesting
MrGilbert
As you can see, he has a beard, so…
djmips
Or tested too much..
ClassicJesus
Is there any blogpost or website to get my mind unstuck on toothpaste? I feel this market is extremely confusing and I don’t know what to buy anymore.
EU citizen here.
haltcatchfire
I'd appreciate that too. My dentist recommended me to use Duraphat, a 9 euro per 50 gram toothpaste.
stefantalpalaru
[dead]
jmward01
I wonder if this will fall into 'supplement' territory for US approval in toothpaste. I can imagine there would be a lot of manufacturers throwing it in without testing to see if their formulation actually works or not.
vhodges
Did they mean route as in path to a solution? Or root as the source? Seems odd.
altairprime
“The root of the problem” is a more usual usage, but is just as readily applied (ha get it) as “the root of the solution”, especially when a dental pun can be bonded (puns are swell) to the headline (I can’t think of a way to pun on gumline here).
I found the phrasing really difficult to read and understand, even though I got the pun, so you’re not alone in that.
brnaftr361
Root as in seed [crystal], as in nucleation point is what I would surmise.
__alexs
Dentistry pun? Root as in the root of a tooth?
iaw
I recently started using a nano-hydroxyapatite based toothpaste. It can't restore enamel but does better at remineralization than fluoride, hopefully it will be a good intermediate for me until something regenerative is available.
chucky_z
To everyone reading this you should still use flouride! Flouride and nanohydroxyapetite together both strengthen the outside layer of your teeth while strengthening the inside of them. Either alone is good, both together are great.
iaw
Oh! To clarify. I use fluoride in the morning and hydroxyapatite at night.
lend000
It seems to me the two are effectively the same unless you have significantly misshaped teeth (remineralizing vs regenerating). I also use hydroxyapatite, just to reduce my fluoride exposure, although I believe fluoride is supposed to be a more potent remineralizer (and fluorapatite is allegedly stronger than natural hydroxyapatite). But the upside is that I don't mind swishing hydroxyapatite around in my mouth for 10 minutes, twice a day, so whenever I go to the dentist, I'm the healthiest mouth of the day (not the case pre-hydroxyapatite tooth paste/powder).
BenjiWiebe
What product(s) do you recommend? I'm in the US.
gamblor956
NHAP particles are smaller than fluoride particles, so they're able to penetrate farther into the porous surface of the teeth; flouride basically can only coat the surface. There is some research indicating that NHAP is more effective than flouride at remineralizing (e.g. https://pmc.ncbi.nlm.nih.gov/articles/PMC4252862/) but that flouride is more protective than NHAP because NHAP isn't protective at all. (The flouride creates a temporary sacrificial enamel-like shell layer that closes off pores in the surface of the teeth in addition to buffering acids; the NHAP will just create new enamel.)
My dentist says that NHAP is great if you have lots of cavities or drink lots of acidic drinks like soda, but once your enamel is repaired too much of NHAP can actually cause weird growths.
Dave's toothpaste has both NHAP and flouride (and the sensitivity agent used in Sensyodyne) if you're looking for the best of all worlds in the U.S.
krackers
>Dave's toothpaste has both NHAP and flouride
And has an RDA of 101. Why on earth would a toothpaste meant for sensitivity have this high of an RDA? (Non-whitening sensodyne is around the 40s)
eth0up
Hydroxyapatite based paste is incredible, and has astonished a few of my incredulous friends dealing with dental problems.
It always seemed very interesting in a cynical way that Sensodyne Repair and Protect has a European version with hydroxyapatite but doesn't offer it in the US. The only reputable US brand I'm aware of is Dr Collins Biomin, which is excellent but weak on the hydroxyapatite.
I'll be abused for it here, but I'm intractably convinced the ADA and generally despicable US health industry prefer to avoid it due to its efficacy and how much revenue would be lost if it were more common. Say what you will against this, and I'll remain convinced.
pimlottc
AFAIK the European version of Sensadyne Repair and Protrct uses Novamin, not Hydroxyapatite. From what I can tell, they are similar but separate chemicals.
While not sold directly in the US, Sensadyne with Novamin is available from Amazon (usually from India).
eth0up
Thanks for clarifying that. I'm confused that my head still insists there was hydroxyapatite involved, but I believe you're correct. My information is over a decade old though.
majkinetor
Not everybody agrees: https://www.youtube.com/watch?v=EYqP5y3iYHo
eth0up
I appreciate the info, but it honestly seems this person is blabbering, barely presenting even anecdotal evidence and literally just saying it's bad because she thinks maybe it is, because, hey look at my friend over here who nods. Definitely makes me wonder if the "Dr" in her handle is more than text.
That said, I'm not surprised people argue against it. But my teeth haven't "crumbled" after more than a decade of regular apatite use, and that's under various impacts and hard use. If there's any validity to her concerns about it, she should actually discuss them, instead of talking about charcoal and her friend.
ungreased0675
I pick up a couple tubes of that Sensodyne every time I’m in Europe.
BenjiWiebe
What product(s) do you recommend? I'm in the US.
chucky_z
Smart mouth has a flouride + hydroxyapetite. I’ve been using it for a few months now and all my tooth pain is completely gone. I’ve been dealing with issues for years and have a wonderful dentist but really had to get myself in shape and brush 2x and really floss correctly. Anyway, that toothpaste also helped compared to only stannous fluoride paste.
eth0up
Either Biomin, or my first choice, Apagard (from Japan).
Biomin is cleaner, but weaker.
I generally choose Apagard though. If you do too, the Premio is a good version with a substantial hydroxyapatite content.
Try to buy from a reputable seller if Apagard. I'd not worry about Biomin much.
Edit: also note that these are rinseless pastes, intended to remain on the teeth for as long as they linger. This is where Biomin has an advantage, being cleaner. Spitting is fine, but rinsing will reduce efficacy.
Edit II: Some will wail in disagreement. I think a waterjet can literally add years to the average lifespan while helping with oral health. Maybe consider one, with simple design and minimal features.
gamblor956
Dave's is available in the U.S. and has NHAP, flouride, and the anti-sensitivity stuff from Sensodyne.
null
rsync
Strange to see this at 246 points on the front page and no mention of bioglass such as novamin?
Is this mechanism different?
The picture says "enamel-mimicking" and the text says "protective coating that mimics the structure and function of natural enamel", so it looks like a protective layer, not true repair. I've been using a paste with novamin lately, it also creates a protective layer and is also marketed as "repair". I like it and feel some heat when it contacts with teeth, so the chemical reaction must be working. But the marketing leaves a bad taste in the mouth.