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The Continuing Crisis, Part IX: Inside the NIH Now

forgotpwagain

It is worth mentioning that China is heavily investing in biotechnology and they are getting genuinely good at the more commodified parts of the industry. This blog post [1] is long and aimed at a biotech expert audience, but one summary line that stands out is that "the drug industry is having its own DeepSeek Moment" [2].

To that end, I believe that this is the time to invest in the US biotechnology ecosystem so that we remain competitive with China. The ongoing crisis at the NIH is antithetical to this goal, as Derek Lowe's blog posts describe.

[1] https://centuryofbio.com/p/commoditization [2] https://www.wsj.com/health/pharma/the-drug-industry-is-havin...

tkel

Honestly it's odd and out-of-touch to be motivated by being "competitive with China". Who cares? If you are a normal US resident, you care about improving the lives of you and your community, not competing against some far-away nebulous group of people whom you have never met and will never interact with. All while big brother is telling you that those far-away strangers are somehow your enemies. It makes sense as a rhetorical way to motivate action, but it's rather simple, short-sighted, manipulative, and divorced from reality for 99% of people.

I also reject the notion that progress is a zero-sum game, that we have to "compete" at all, that there needs to be a winner and a loser here. We could just as well work with others to improve the lives of us and our communities. Why isn't the notion "cooperate with China to uplift all"? Perhaps releasing your models under a MIT license is actually the right move here that is in everyone's best interest, perhaps the US should be following their lead?

nradov

Sounds good, but in the end possession of sovereign territory is a zero-sum game. Perhaps you could convince the Chinese Communist Party to stop trying to seize it from our allies? Because allowing China to dominate the Indo-Pacific Region certainly won't benefit normal US residents in the long run.

gttalbot

Much too quiet here on HN on this post

Science underpins technology, people.

If you want to see the US rapidly lose its place in the tech world over the next decade, this is a great way to go about it.

jvanderbot

Yes of course.

The problem is what can be done? The usual arrangement of letter writing or donating and voting is just more of the same cycle.

I'm not by any means in favor of what's going on, but some steam has to be let out of the system. And the real problem is trust in our institutions. What can be done about that?

adamtaylor_13

My thoughts exactly. I certainly have throes of people on Facebook complaining about this, but what shall I, the individual, do about this?

I have my causes to which I devote great time and personal effort, but if I stopped my life for every minor disaster I would spend my life shaking my fist at my computer.

I quite like my life and I don’t intend to spend it getting rage baited by never-ending news cycles.

Give me an action to take, not an emotion to feel.

davidw

I'm nearly 50 and have watched politics swing back and forth all my life.

That's not what is currently happening. It's not a minor disaster. It's something we'll take generations to recover from, if ever.

We can't do much, individually. Find people in your community working on stuff you care about and get out there and pitch in. Get involved. Make sure your local school district isn't banning books or being cruel to trans kids. Make sure you have good city councilors.

A friend of mine made this in the area where I live: https://deschutesgrassroots.com/

BenFranklin100

How old are you? What is happening now at the NSF and NIH will knock the US off its technological perch in less than 15 to 20 years. We are already fighting to maintain an edge as it is.

What this means to you personally and other tech workers is that many of the well-paying tech jobs will be going elsewhere.

MaysonL

Call and write your Congresspeople. Picket a Tesla dealer. Get vaccinated.

null

[deleted]

ModernMech

Chain yourself to a Tesla dealership. I'm serious. Getting Elon Musk to cry about how unfair he's being treated on TV amidst the damage he's doing will do more to hasten his departure than any letter or check you can write.

johntitorjr

Mass protests and non-violent civil disobedience. I hope that we don't reach a point where going beyond that is required.

yesdocs

Yes, civil disobedience. Get into ‘Good trouble’

bloomingkales

[flagged]

jimbokun

It's the exact opposite.

Tech platforms censored a lot of right of center content, thinking it would mean those ideas would disappear.

Instead Musk took over Twitter, right leaning podcasts became far more popular than left leaning podcasts because they were willing to engage in controversial topics, and now Trump and Musk control everything.

But, you know, keep trying the same thing and hoping for different results.

A thought experiment for you: how do you think the audience of Hacker News compares to Joe Rogan? And your focus is seriously on censoring more content on Hacker News to move the needle in national politics?

grandempire

> on the wrong side of history

I don’t think history is a progression of superior morals or thinking, or that there are ethical “sides” to it.

SecretDreams

I've noticed on HN that any post involving less wholesome takes on the US admin and/or doge leadership become brigaded quite heavily with more lower quality discourse than the normal fare.

It's a really interesting phenomenon. And I'm kind of surprised the community allows it.

davidw

TBH, politics is and should be taken elsewhere because it is much more important than most of what we discuss here and therefore could easily crowd out everything else.

SecretDreams

But there's a strong intersection between STEM, policy, and downstream innovation/employment - not to mention any ethical dilemmas along the way.

Not discussing and/or allowing bots to overrun any such discussion and drown out dissent has never in the history of man left to immediately better times in STEM.

lolinder

> Much too quiet here on HN on this post

This whole topic has been done to death on HN, and this post doesn't contribute much that hasn't already been discussed extensively. Science underpins technology, but we've had 2-3 DOGE-related topics pinned to the front page at a time nonstop since the inauguration and the subject is bleeding incessantly into every other submission on the site.

Rest assured you'll have another 500+ comment rage fest in the near future, probably this week. This one just doesn't have enough going to feed the rage spiral—it's pretty blase compared to the dosage we've worked ourselves up to.

bloomingkales

[flagged]

jmclnx

>If you want to see the US rapidly lose its place in the tech world over the next decade, this is a great way to go about it.

Too late, unless DOGE is stopped now and Trump is impeached, the US will lose its lead in tech and health (pharma) and many other industries. Pure and simple. Already the smartest of the smart are leaving the US for Europe and probably China.

If this is allowed to continue, in 6 months to a year, the US will be isolated and a third rate economy. All it will have is a first class war machine, which will not bode well for the world.

jimbokun

> All it will have is a first class war machine

And that won't last for much longer after losing those other sectors, either, as military dominance is a function of economic and technological superiority.

ModernMech

If things go for much longer it'll be too late. In many ways it already is. Scientists I know are changing careers. Thinking of moving. Other countries are thinking about how they can take advantage of the brain drain. Even if things turn around today so much damage has been done already that it'll be felt for a long time.

denom

The post war scientific edifice is being shattered in a monumental act of vandalism.

It’s not just defunding childhood cancer research, but also dismantling the very idea of agency in the broader society. Science and basic research are worth pursuing. And the cost is a pittance.

grandempire

How do we know what projects are worth funding? Anything that labels itself science? Is sociology science and basic research? Do we fund people instead of projects? How do you get in the group?

acdha

These grants are competitively reviewed by experts in their fields, and are quite hard to get. Even twenty years ago getting an NIH R01 was considered an important career accomplishment.

Now, as to the topics being funded, the broad strokes are set by Congress, which is why much of the funding goes to medical research since pretty much everyone likes the idea of better treatments for things like cancer or Alzheimer’s disease. If there was an entire field they considered unnecessary, the legal process would be working with Congress to either remove it entirely or put in restrictions. They aren’t doing that, of course, because that would force people to actually go on the record voting for something specific and that usually exposes that “junk science” claims are deceptive.

queuebert

> Even twenty years ago getting an NIH R1 was considered an important career accomplishment.

R01

brookst

I can’t read between the lines you’re drawing. Are you trying to say that unless we can make perfectly efficient funding decisions, we should fund nothing?

grandempire

The concern is that we are defunding important things because science is getting cut. But every university group associates itself with science.

Saying “we have to fund science” is a sentiment which is synonymous with saying “we have to fund good research projects that help society”.

Which important efforts are we losing? Or which are essential to keep?

brookst

The oligarchs can’t stand to see a single dollar go to a legit purpose though.

linguae

This reminds me of something Alan Kay (of Xerox PARC and Apple fame) wrote when talked about how those who profited from the results of research have not “paid it forward” through funding future research:

https://worrydream.com/2017-12-30-alan/

“As I pointed out in a previous email, Engelbart couldn't get funding from the very people who made fortunes from his inventions.

“It strikes me that many of the tech billionaires have already gotten their "upside" many times over from people like Engelbart and other researchers who were supported by ARPA, Parc, ONR, etc. Why would they insist on more upside, and that their money should be an "investment"? That isn't how the great inventions and fundamental technologies were created that eventually gave rise to the wealth that they tapped into after the fact.

“It would be really worth the while of people who do want to make money -- they think in terms of millions and billions -- to understand how the trillions -- those 3 and 4 extra zeros came about that they have tapped into. And to support that process.”

throwaway657656

No, this isn't about oligarchs. This is about sadists some of whom happen to be oligarchs whose singular goal is to make the non-MAGA sad. It is working.

bdangubic

it is of course not about that, maga could give two shits who is happy or sad. the whole exercise is too do silly shit in public to make people “outraged” while privately commiting the greatest heist in the history of the universe :)

RRWagner

No, the oligarchs can't stand seeing a single dollar go to the poor, and when one is a billionaire, everyone else is poor.

iimblack

What blows my mind is how short sighted it is. Even the oligarchs benefit from scientific research. Even the oligarchs lose money when our industries move to other countries.

marcus_holmes

But... why?

Why would anyone just destroy scientific research in their own country?

What do they hope to gain from this?

makeitdouble

https://en.wikipedia.org/wiki/Great_Leap_Forward

> The Great Leap Forward stemmed from multiple factors, including "the purge of intellectuals, the surge of less-educated radicals, the need to find new ways to generate domestic capital, rising enthusiasm about the potential results mass mobilization might produce

marcus_holmes

Yeah, I guess. Destroying the political "enemy" becomes more important than anything else.

I thought that only happened in socially backward, ideology-riddled, far-off places like Cambodia or China. Not advanced Western democracies.

makeitdouble

As a disclaimer, I don't know any country that is dealing with these kind of issues really well. Some don't have the struggle, but IMHO not just because of wise government and more thanks to historic or geographic position.

Destroying the political enemy has always been more important that anything else. Straight jailing "communists", jailing opposing minorities (crafting legal frameworks to do it or straight asking the army is to me the same), cutting funds from whole industries to help one's base and crush the other parties funds, taking money from enemy states to win domestic elections etc.

It's a matter of what you get flack for and what flies below the radar.

Developing countries have more visible incidents because their economy is more fragile and any political swing will have huge life and death ramifications. In contrast the US can afford waging trade wars without floods of people out in the streets.

krapp

"Socially backward" and "ideology riddled" describes the US pretty well.

And "far off" in the sense that American culture is intentionally isolationist and separatist, and Americans tend to be aggressively ignorant about the rest of the world.

Most Western democracies are more safe and have a higher standard of living and score better on the Human Freedom Index and other metrics than the US, and have "advanced" features like socialized healthcare and education, which the US does not, so one could argue the US isn't even advanced as Western democracies go. Having one's system of laws based on the vague and archaic prose of a Constitution written for an 18th century pre-industrial agrarian slaveowning society isn't very advanced as far as modern constitutional law is concerned.

linguae

A thought occurred to me as I was reading your comment: what if this thinking that what we're witnessing couldn't happen in "advanced Western democracies" that are not "socially backward, ideology-riddled, [and] far-off" is one of the factors that helped us get to this situation?

All societies have "socially backward" and "ideology-riddled" aspects to them. American society has long struggled with racism, xenophobia, sexism, and anti-intellectualism, just to name a few of these ills. For example, the Eisenhower years that many people consider America's peak were also years where African Americans still had to endure Jim Crow, though to be fair this era was also the beginning of the Civil Rights movement, were many people fought to secure civil rights for all Americans regardless of ethnicity. McCarthyism and J. Edgar Hoover's abuse of authority were also happening under these times. Nixon had his infamous "enemies list." Police brutality and the violent suppression of non-violent protests have been an ongoing problem. Speaking as an American, our nation has been far from exemplary when it comes to not destroying political "enemies," from whistleblowers to protestors to entire ethnic groups.

Granted, the federal government has been able for much of its history to avoid fully caving to the desires of the "socially backward" and "ideology-riddled." Unfortunately, demagoguery is sometimes an effective strategy, and to be frank, our oligarchs and our politicians in general have done a poor job since the 1970s of building an environment where everyday Americans have an opportunity to improve their material lives. The past 30 years in particular have been a bonanza for asset holders, successful entrepreneurs, and other well-connected people, but it seems that life has become harder for the average low-income and middle-class American, especially as the prices of health care, higher education, and housing have gone up far faster than many Americans' ability to pay for these things. This has left behind many people, and many people feel like the "American dream" is dying or even dead. Unfortunately this hopelessness is a breeding ground for "socially backward" and "ideology-riddled" thoughts to take root, and the resulting field has become ripe for demagogues to pick.

We are now dealing with the results of this. Democracies are not immune to this; similar political movements in France and Germany have been picking up steam in recent years.

I don't know how we could reverse the tide in America right now, but I hope and pray that this does not spread to places like Canada, France, Germany, and other stable democracies. I think the key lies in having leadership, not just governmental but also in business and in other social institutions, be more caring about the societies they are established in. It's much harder for demagoguery to be effective when people feel secure and hopeful about their lot in life.

jimbokun

Bingo.

In MAGA land, educational institutions are coded as woke and DEI infested.

jmclnx

Because, many autocrats do this, a recent example is the Cultural Revolution in China. It took 50 years and a lot of hard work for China to recover from that.

Destroying the educational system allows these people to consolidate and maintain power.

linguae

1. It’s about the culture wars and also “evening the score” against opponents of Trump and MAGA. The Trump administration seems to be hellbent on “sticking it” to people, groups, institutions, and even nations that opposed him. Scientists and academics in general are on his hit list. There has always been an anti-intellectual bent on American society, but never have I seen it weaponized like this. Moreover, it’s unlikely that such policies will face blowback among Trump’s voting base. There are conservative scientists and academics whose careers have been upended by these moves, but they are a minority, and there aren’t enough of them to significantly erode the GOP’s electability.

2. It’s also about power and control. “He who pays the piper calls the tune,” and Trump and his administration are reveling in their abilities to withhold federal dollars (paid for with the tax monies from all American taxpayers, Trump- and non-Trump voter alike) from targeted agencies and institutions unless they meet whatever diktats they demand.

It’s a scary time for science in America now. Science is already dealing with the “publish-or-perish” culture of academia, the fact that academics are pressured to raise recurrent streams of grant money in order to earn tenure, and the fact that industrial labs are increasingly driven by short-term business pursuits instead of longer-term, more speculative projects. These disruptive freezes of NIH and NSF funds, as well as the targeted attacks on universities such as Columbia and UPenn over culture war matters, are reckless and destructive. If this does not stop soon, this could set back American science and research for decades.

turtletontine

The biggest motivation IMO is just punishing universities. The first move cutting overhead costs made this pretty clear to me. It was a shrewd move: if you squint, and use no critical thinking, you could be convinced they’ll still fund science all the same but are forcing university bureaucracies to be more “efficient”. In practice it’s just a massive cut to research universities, cause they’re viewed as enemies of the current ascendant right.

The other thing, IMO, is that it’s admitting we have no longer have any aspiration to technical innovation. If the tech oligarchs actually depended on hiring “the best and brightest,” they’ve be fighting this tooth and nail. Instead, they’re perfectly happy to destroy the education pipeline because they no longer need to make good products. They’ve attained monopoly status: all they need are lobbyists and a good legal team, the quality of their product is irrelevant. (The only spot where they still seem to be competing is “AI”).

baggy_trough

I think your first paragraph is closer to the truth. Going after the "commanding heights" of progressivism is the goal. That's also why the federal bureaucracy is being targeted.

acdha

The two broad things I see are that academia has for years been claimed to be an extreme-left wing indoctrination complex, increasingly broadly targeted as things like climate change denial became Republican loyalty tests, and medicine became a special focus as anti-vaccination became a core belief. This works as a political ad telling people that they’re really hurting their enemies.

The other big goal is probably financial: they really want to give rich people tax cuts, and there’s no way to do that without cutting social programs like Medicaid which even their voters want left untouched. They appear to be continuing to claim that there is so much waste and fraud that they’ll be able to pay for it by cutting that, and hoping that people will be distracted until it’s too late. Based on the 2017 version, I’m expecting some kind of time-delay where the tax cuts kick in immediately but cuts aren’t forced until after some very “optimistic” growth predictions fail to materialize.

foxglacier

[flagged]

acdha

You’re making two big mistakes in that comparison. The obvious one is simply magnitude: people are losing funding for entire labs and research projects years in the making, which details careers and destroys capacity which will have to be rebuilt when America resumes funding research.

The second error is conflating the impact on research: losing a grant _prevents_ science from happening but those DEI changes were very minor additions to an existing research program. Doing outreach doesn’t harm science, and often helps the researcher improve their ability to communicate their work to non-specialists. Considering a wider range of students or employees similarly doesn’t hurt research: you still didn’t have to hire someone unqualified, but maybe you gave a chance to someone from a less-prestigious university. In some cases, it even made for better science: for example, medical and safety research being careful to include women in their experiment planning benefits half of the population.

Henchman21

PERHAPS, and bear with me here, I know it's gonna be a stretch...

Perhaps those scientists you think ought to have been protesting "DEI" had zero problems with it? Perhaps they actually supported it? Perhaps that "statistic they dredged up" was actually meaningful to them and their community? Nah, can't be that. Must be them simply hungry for cash. Not a desire to do research, just basic human greed. That's really all they're capable of, right?

sunshinesnacks

Are you suggesting that NIH isn’t valuable to society? Or that the people fired with no justification deserve it because not enough scientists protested DEI grant requirements?

Just because scientists want to be paid doesn’t mean they aren’t worth having around.

marcus_holmes

Even if that was true, and as big a problem as you say it is, realign the incentives.

Don't rip the whole thing down and throw the baby out with the bathwater.

Put it like this: if Trump was a Russian agent attempting to destroy America, what actions would he be doing differently to achieve that? Destroying basic scientific research would definitely be step in that direction, right?

georgeburdell

You’re not wrong — I have my own experience in padding my work with DEI drivel to get a grant — but the solution isn’t to salt the earth