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Aspartame aggravates atherosclerosis through insulin-triggered inflammation

kreetx

Every now and then there is an alarmist article about aspartame, and every time it's hard to tell whether moderate drinking of soft drinks is better when it had regular sugar vs when it has aspartame - can any person more familiar comment on this with regarding to current article?

anon373839

The funny thing about this question is that it doesn’t really matter, unless it does: Sugar harms your health in a whole host of well documented ways, but a little of it, infrequently, is fine. Aspartame has always been under a cloud of doubt, but is probably also just fine in small amounts.

So really, you only need to be thinking about this if you’re having either of them as a regular part of your diet. And if that’s the case, well, this is the part where you really should listen to all those people who recommend that you acquire a taste for water.

shlant

> Aspartame has always been under a cloud of doubt

But this is almost entirely due to alarmists who were never using good science to justify their perspectives (just like with MSG). The reality is that aspartame is one of the most studied substances in history and it's effect on humans is very clear.

kreetx

My main question is, if I drink ~3 glasses of soft drinks per day, should I get the one with sugar or the one with aspartame. Currently, I get the one with aspartame with thinking that (1) given the amount of sugar in this amount, I'd be running 100% full of my daily sugar norm, and (2) there are no conclusive evidence of aspartame being actually bad. Would the sugary drink be a better choice?

Another thing that irks me (though less so), is that occasionally somebody says for an aspartame drink that "you're drinking that poison?", when clearly, we would know if it really were poison.

Saris

3 glasses of soft drinks is an insane amount of sugar on a daily basis, so if you have to do it you're probably better off with the aspartame.

orev

One school of thought (including my own) is that if you’re consuming enough sweetened products per day that you need to consider switching to ones that contain artificial sweeteners (to avoid too much sugar), then it’s time to re-evaluate your lifestyle by questioning why you’re consuming so much sweet stuff to begin with. There are so many other foods that have so many other enjoyable flavors and well-known health benefits that you can make room for in your life.

pants2

Sugar has extremely well documented negative effects even in the amounts you find in a regular soda (let alone three). Most of the Aspartame studies test massive doses and are generally inconclusive. If it's a choice between the two, go with the Aspartame.

vlvdus

I believe your options are glucose–fructose syrup or aspartame - I'd lean towards aspartame as well. If sugar was an option I'd gladly cut the daily intake and go with that.

jadbox

It's almost like humans are naturally tuned to drink plain unsweetened water.

Spivak

And yet we've been dissatisfied with and flavoring our water for longer than we have recorded history.

ygjb

For most of recorded history that was because we didn't have access to food, clean water. The process of preparing alcohol, tea, coffee, and other beverages was part of making water safe to deinkt. Alot of the world still doesn't have access to reliable, clean water.

Now it's because of advertising telling us to drink anything but water (or if we drink water to buy it in a bottle).

jmulho

Gil Carvalho (Nutrition Made Simple) is a good source for these types of questions. His existing videos may not address a brand new study, but he will give you a basis for assessing the new study in the context of what is already known.

https://www.youtube.com/watch?v=NdKAPzsxr_Y https://www.youtube.com/watch?v=5h5IABzlj8w

shlant

a good rule of thumb is to not make significant changes based on single studies - especially on mice, ESPECIALLY in regards to controversial subjects. Robust science is not built on single studies.

edhelas

Just drink water or low sugar beverages.

mort96

I do!

Problem is, those low sugar beverages are often low sugar thanks to aspartame

rgrieselhuber

That’s not what health-oriented people mean when they say “low sugar” - that’s part of the marketing trick of these drink manufacturers. Low sugar means water, unsweetened tea, coffee without sugar, etc. Simply replacing sugar with toxic chemicals and calling it low sugar is insanity.

RajT88

Fizzy water

morkalork

I would really like a low sugar soft drink, not artificial but one with like 1/4 the amount of real sugar. It would probably taste fine, I don't get why everything needs 32g in it!

jmulho

My favorite (besides water, coffee, tea) is sparkling water with some fruit juice and no added sweeteners, e.g. the brand “Spindrift”. It’s 35 calories. I prefer it to colas, juice, and sparkling juice. It is particularly refreshing when you are hot (from yard work, exercise, etc.) when other drinks can taste too sweet.

closewith

I went through a phase of making homemade cola syrup and then carbonating it with a home carbonator to get a low-sugar cola without sweeteners (which I used to tolerate, but which gained an awful taste following a bout of COVID-induced anosmia). For me, that ended up being about 4g demerara per 100ml.

procaryote

making your own lemonade is awesome! You can tune the amount of sugar and lemon you want, from "water with a drop of lemon" to whatever you like. Put some fresh mint in there if you like

If life didn't give you lemons, you're out of luck though

didgeoridoo

DRAM makes a line of reasonably-sweetened sodas (3-5g sugar per can) but they’re definitely a “luxury” product, in the range of $10-15 for a 4-pack. I don’t know of a single mass-market option.

flyinghamster

Sports drinks. Maybe not 1/4, but 1/3-1/2 is certainly doable. The one in front of me is 150 calories per 28 oz, versus similar levels per 12-oz. serving for typical soft drinks.

lifeinthevoid

Kombucha can be low sugar and the acidity is quite nice.

bfmalky

Buy diluting juice. Water it down to your preferred concentration.

ohgr

This is why I drink water. And water with coffee in it.

lenerdenator

I know that they've gone back and forth on artificial sweeteners over the years, but honestly, one of the best things I've done recently is switch over to seltzer water. Triggers all of the chemical receptors in the brain by repeating the "ritual" of drinking canned pop, but it's just water, so it's actually good for you. Also half the cost.

flocciput

I've found seltzer makes me sleepy or fatigued for some reason. Everyone I tell this to looks at me like I'm nuts but I swear it's real. I think it has something to do with the brain's expectation of calories and the subsequent lack.

deinonychus

I can imagine that. If I drink a lot of diet soda, I get a bit wired but also tired in a weird way. It's like my body expects some sugar to fuel the caffeine's stimulation.

MrMcCall

I get sleepy if I have too many vitamins/minerals (eg: a whole PowerBar or entire Orgain drink), so maybe it's the minerals, perhaps Magnesium?

[Magnesium helps my wife sleep better, but she can only take it at night or it makes her sleepy. I take half in the morning, and I think it helps because we're likely not getting enough in our mineral-depleted foods.]

lotsofpulp

https://pmc.ncbi.nlm.nih.gov/articles/PMC10096725/

>People with little saliva and a habit of frequently consuming acidic beverages are at increased risk for enamel erosion. The basic recommendations are to drink water as the first choice and eat fresh fruits as an integral part of a healthy and balanced diet.

>Health professionals should motivate the population to change their behavior regarding the consumption of acidic drinks, and recommendations should be made at the policy level to discourage the consumption of sugary drinks. Interventions that would improve oral health and overall health are widely available.

StableAlkyne

Harm reduction is important.

Normal sodas are pretty acidic - coke has a pH of around 2.5

Soda water has a pH of 5-6.

Your saliva has a pH of around 6-7.

Water, of course, is at 7.

Remember we're dealing a log scale here, and that going from 2.5 to 5.5 isn't a 2x improvement - it's closer to a 1000x reduction in the amount of acid. If replacing soda with soda water is what gets them to stick to it, that's what they should do.

cj

I switched from sparkling to plain water a few weeks ago (for other reasons).

I’m drinking significantly less than I was when drinking sparkling.

So again, the question now becomes is it better to be fully hydrated drinking “acidic” sparkling water, or is it better to only drink plain water and be dehydrated? (Rhetorical question)

null

[deleted]

seamossfet

From that same study:

>The increased amounts of calcium, phosphate, and fluoride in the drinks limited the severity of erosion by changing the solubility of the enamel [82]. The decline in enamel’s surface microhardness and mineral loss were both dramatically halted by the addition of CaGP to the carbonated drinks.

Most seltzer water has fluoride in it, and your tap water has fluoride in it (if you're making your own at home).

Also the methodology in this study was purely in vitro, not real world conditions. Notably, the lack of saliva.

>Under normal circumstances, human saliva forms a physical barrier, a film, and prevents direct contact between the tooth enamel surface and acidic beverages, thus protecting teeth from erosive attack by acids [45,84,85,86]. However, the erosion tests were carried out without saliva

Also, seems like the study was more on soft drinks in particular and not "other acidic drinks" which may include seltzer water.

>Soft drink consumption during meals was linked to mild to severe tooth damage [65]. No matter when they were consumed, other acidic meals and beverages were not linked to tooth damage [40].

Anyway, net is this: I'm not saying sparkling water carries absolutely no risk, but linking a study like this and cherry picking quotes to make it sound like sparkling water is going to destroy your teeth is misleading.

If drinking sparkling water helps you kick your soda habit, please definitely make the switch. It's so much better for you. The increased risk from drinking sparkling water compared to still water is not worth worrying about if sparkling water provides a quality of life increase for you.

Everything in healthcare is about moderated risk and counterbalancing it against lifestyle.

amelius

Exposing your bladder to a lot of CO2 might not be a good idea.

thyristan

To arrive in the bladder, the CO₂ would have to be absorbed into the blood stream first. Which it isn't, it is just burped out from your stomach. Also, CO₂ which is dissolved into the blood stream is removed through your lungs, and the blood CO₂ level is very tightly controlled by various regulators and reflexes. You would know instantly through your suffocation response that your blood CO₂ is elevated.

marceldegraaf

Why would that be? I'm no biologist but I'm quite sure the CO2 won't make it all the way to the bladder, when drinking plain carbonated water.

kvgr

A lot of carbonated water gives me gas, especially when not eating enough. But I am not sure it is an issue. People have various gas levels, it just goes in and out.

wyldfire

If gases show up in your urine, something has gone seriously wrong.

eemil

What's with the double standard, around sugar and artificial sweeteners?

Artificial sweeteners do not need to be as safe as bottled water.

They just need to be less harmful than sugar. Which they are, because sugar is unequivocally, very very bad for you.

simonsarris

> because sugar is unequivocally, very very bad for you.

So all fruit is bad for you? Lactose is unequivocally bad? Even for nursing infants? How deep does "unequivocally" go exactly?

I hope you really just mean "added sugar in soda-tier quantities" when you say sugar is "unequivocally, very very bad". But I think this kind of hyperbole is part of why food science has got an awful reputation. Even the most 'enlightened' sources (and there are plenty of competing enlightened sources right now) seem unable to stop the totalizing language.

niam

One refrain seems to be that "added sugars" are bad but then that's not quite true afaik either, because sugar is sugar whether it's "added" or not.

To a first approximation, "sugar is bad for you" seems to be a succinct lie-to-children[1] default, from where exceptions can be established. Whole fruits with lots of sugars (as opposed to e.g fruit juices with a comparable amount) are purportedly less-bad because they're accompanied by enough fiber to slow digestion and make the sugar less bioavailable.

[1]: https://en.wikipedia.org/wiki/Lie-to-children

mmaunder

How well established is it that aspartame produces an insulin response? For me that’s the shocker. I don’t consume any but I’ve always suspected this. It suggests that many diet sodas, sugar free gums, and sugar free foods can contribute to insulin resistance and type 2 diabetes.

klipklop

In mice with their genes edited and taking in 0.15% of aspartame in their diet. How am I supposed to take this seriously?

glimshe

Over the years I got out of all carbonated drinks and excessive coffee by phasing in homebrewed black, green and herbal teas. I feel a lot healthier and my previously chronic heartburn and gastritis magically went away.

coffeecantcode

Yup, I was never much of a soda drinker but switching from coffee to loose leaf teas has been a huge move for me in my daily habits. I used to drink coffee until 3, 4, even 5pm and it was having negative effects on my health and sleep.

Now I just start the day with a mug of loose leaf tea and keep re-steeping it as the day goes on. By the time noon comes around there is little to no caffeine left but I still get some tea flavor as well as the hit of hot liquid my body is used to.

When at home I brew gong fu style which keeps more caffeine as I reload the gaiwan or tea pot but that’s just a preference of mine. Highly recommend Chinese/Taiwanese teas, especially Oolong if you’re looking for an alternative to coffee or soda.

nonethewiser

TIL aspartame is considered "healthier" because it takes far less of it in calories to achieve the same level of sweetness (~200x sweeter than sugar).

Havoc

Been avoiding it since day 1. At least with sugar the risks are somewhat understood.

Then again...don't drink soda so neither here not there really

SketchySeaBeast

This feels kind of like "at least I know what I'm getting with the measles".

shlant

> At least with sugar the risks are somewhat understood.

Aspartame has been studied for 50 years. The risks are very well understood. This single study on mice does not shift that.

nisegami

So it sounds like: 1. consuming aspartame triggers insulin release (unclear if this is novel information) 2. insulin release triggers inflammation that leads to atherosclerosis (they go into further detail on the mechanism here, which appears to be novel info)

It really doesn't seem to me like the artificial sweeteners should be the critical aspect of this finding, as this affects anything that triggers insulin release. Is there any data linking sulfonylureas with atherosclerosis? Based on this finding, one might expect that to be a consequence of their insulin releasing effect.

elhudy

I didn’t read the entire article and i am not a physician.

That said, your point #2 sounds incorrect - aspartame doesn’t cause atherosclerosis, it aggravates atherosclerosis. The key difference there as it relates to type 2 diabetes patients is that presumably if they had atherosclerosis as an existing condition, they would qualify for a glp-1 with cvd benefits, and not be on sulfonylureas in the first place.

sambeau

Sometimes I'm glad that artificial sweeteners taste incredibly bitter to me

kypro

> Here, we show that consumption of 0.15% aspartame (APM) markedly increased insulin

Most food will "markedly increase insulin", and sugary food / drinks even more so.

Obviously people should try to eat healthy and ideally avoid artificial sweeteners, but in reality people are not machines and they're not going to drink water and eat lean meat and veg every day just because that's what's best for them.

It seems to me that for most people who like to occasionally consume soft drinks that switching to a comparable artificially sweetened alternative is going to be better for you even if there are still risks.

A study titled "eating cake aggravates atherosclerosis through insulin-triggered inflammation" isn't reason to never eat cake. It's just reason to be sensible and consume in moderation.

People have been consuming artificially flavoured foods and drinks daily for decades at this point. While these things are interesting to know and consider, no one should be concerned about this unless you're consuming an excessive amount of Aspartame. And even then it's almost certainly better for you to do that than consume excessive amounts of sugar.