How Excessive Red Meat Consumption Increases Colorectal Cancer Risk
61 comments
·October 25, 2024naming_the_user
aziaziazi
Average hn reader needs more sun exposure than he does because the vitD boost will probably worth the cancer risk.
With red meat the known benefits peaks (way) lower than average consumption. I’m not an expert but that looks to be shown more than the opposite. On a personal anecdote my doctor tells last week optimum is at 1meal/2weeks. He’s maybe not aware of breaking discoveries but this looks to be in range with what’s discussed here and there.
I like critical thinking nevertheless and it would be interesting to learn more.
naming_the_user
Right. The question remains though about what we mean by "known benefits".
I chose caffeine as an example because I think that it's completely nontrivial to calculate. The physical pathways of things like "well this makes that molecule do this and have some x% chance to mutate and so on and so you get cancer", or the statistical output of "well people in the coffee cohort have % higher rates of this cancer" are much easier to accurately study than things like "if you drink coffee you are 3% more likely to get into law school and therefore become significantly wealthier and probably live a longer/healthier life and we can measure that impact precisely".
It's also not at all obvious that lifespan above all else is the thing to maximise. e.g. maybe red meat reduces lifespan but makes your 20s-60s more fun because you're likely to be more muscular or whatever.
My personal feeling is that aside from really really bad things like smoking, heavy alcohol use, heroin etc the error bars are too large to make decisions purely on long-term health impact alone.
xcrunner529
Why are you so eager to fantasize about some "other benefit" with no evidence whatsoever of it, while evidence is presented on the harmful effects in many studies at this point. Would you think the same way about "poisons" or plastic contamination? Pollution?
Correlation != causation and all of that, but as the US has increased meat consumption and processed foods colon cancer has been on the rise, including younger and younger adults.
fakedang
I wrote this in another comment earlier, but red meat is the most energy-efficient food source available for consumption in digestive terms, simply because our bodies were designed to process large amounts of protein rapidly - compared to plant matter that needs to be broken down multiple times. There's a reason herbivores have 4 stomachs. Human bodies basically evolved as Apex predators and a meat diet helped that, as well as was responsible for it. Meat, berries and tubers for hunter-gatherers to put it succinctly.
We only adopted carbs because back in the day, cereals were the most efficient way to feed a large population (compared to say large-scale veggie cultivation) for an active societal workforce. But with us slowly and inevitably turning into lumbering sedentary creatures, it makes no sense to continue eating as many carbs as we are culturally accustomed to, instead resorting to meats and veggies to adequately cover up that deficit. Unfortunately, you need a ton of veggies to make up that deficit, but you can make do with a much smaller sized portion of meat than you're usually accustomed to (as we see with East Asian diets).
andreasmetsala
Why are you treating vegetarianism as the alternative to red meat?
You can drastically reduce the “redness” of your diet by eating chicken and fish. Even pork is less “red” though I’m not sure if it counts as red meat for this study.
adrian_b
You can get some energy quickly from proteins like meat, but you cannot get enough energy for a day of work.
Humans need to get most of the energy either from fat or from carbohydrates like starch, otherwise they die.
Even for the speed of obtaining energy from food, nothing beats a mixture of glucose with fructose, like long-distance runners or cyclists have to consume, if they want to win.
Red meat may be very tasty, but it is not the best for any criterion. As a source of proteins, lean white meat is superior, e.g. turkey breast, chicken breast or fillet from various kinds of fish with white meat, e.g. cod or zander.
As a source of energy, any food rich in starch or in oil is superior and also many times cheaper.
During the last few tens of thousands of years, the humans have evolved to be much better at digesting starch than their ancestors and than most other apes or monkeys, by increasing the ability to synthesize the enzymes used in starch digestion.
So our body physiology has already shifted somewhat from being best adapted to a hunter lifestyle to one where the plant seeds can satisfy most of the energy requirements.
Meat still remains one of the best choices as a source of proteins, but not as a source of energy.
valval
I’d wait for the results of this study to be expanded upon in any case before claiming causality. I didn’t read the study but I can think of half a dozen reasons why the claim in the article wouldn’t mean higher red meat intake -> higher cancer risk.
I’m fine with other people eating less red meat since that means less competition for me, but I’d still encourage healthy skepticism when people tell you to eat less of something that we’ve eaten since the dawn of our being and replace that in any degree with something novel.
honestAbe22
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bell-cot
Summary: In the lab, using selected "standard lines" of cancer cells, it looked fairly plausible that iron encourages the growth of colorectal cancer cells.
Eating "excessive" red meat seems very likely cause high iron concentrations in your lower intestines. Beyond that - YMMV.
photonthug
> Beyond that - YMMV.
Looking at Inuit and Mongolian populations for stuff like this would likely be a good approach to actually learn stuff. Almost a strictly meat diet, but without all the confounding variables of sedentary office workers, industrial chemicals, and highly processed foods with tons of sugar.
stackghost
There's more to it than diet. Genetics also plays a large role. I'd be leery of generalizing dietary advice across ethnicities.
inglor_cz
... and microbiota, too. Colorectal cancer is located at the end of a very densely "populated" tube.
In all likelihood, Inuit microbiota is very far from Western one, at least as long as they don't adapt Western diet.
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Findecanor
I have heard of there having been earlier studies that have linked iron intake with colon cancer growth, and I have personal reason to believe them.
I have Lynch syndrome: a hereditary cell mutation which increases risk of colon cancer. Patients like me get a colonoscopy every eighteen months or so only to remove polyps. For a decade I had not had a single polyp to remove.
Then in 2022, I got another cancer which gave me blood deficiency (low hemoglobin levels), and just to keep myself alive I took strong iron supplements for months. It did of course also stress my immune system. I got colon cancer in record time, which surprised also my doctors. It grew from no visible polyp (my last colonoscopy) to two inches in nine months, and in-between that I had an X-ray that also showed nothing (but which can't detect tumors small enough).
cynicalpeace
So it's a junk headline? Also, telomerase activation is heavily correlated with longevity and less risk of disease.
riku_iki
Per dietaryguidelines.gov cereal contains 8 times more iron per calory than beef: https://www.dietaryguidelines.gov/resources/2020-2025-dietar...
Bluescreenbuddy
Is this why millennials and early genx are seeing higher rates
cynicalpeace
So the answer is yes, lol
tcdent
The correlation with Iron makes me wonder if the polymerization of cooking oils is related.
https://www.lodgecastiron.com/cleaning-and-care/cast-iron/sc...
jollyllama
I wonder if tea, coffee, wine, phytate containing foods (beans, nuts) and calcium rich foods (dairy, etc) would counter the risk by blocking iron absorption.
fyt2024
Just getting celiac disease would counter iron intake :-)
fyt2024
I remember a paper long time ago that claimed that one reason why women have higher life spans than men is lower iron content in their blood due to menstruation.
homarano
Women have a consistently lower mortality rate than men at all ages 20-80 with no notable change around menopause.
https://www.researchgate.net/figure/Mortality-rate-for-men-a...
QuercusMax
Here's an interesting article that talks about sexual differences in life span, which seems to be correlated with the size of the sex chromosome: https://www.science.org/content/article/secret-long-life-mat...
Basically, for whatever reason, a larger sex chromosome (X is much bigger than Y) confers a better chance of survival.
tuatoru
I thought it was because females have two copies of the X, so defects in a region of one copy can be compensated for by the other. RAID-1 ftw.
DiscourseFan
>This unevenness hints that factors other than the presence of certain sex chromosomes might also strongly influence longevity, the team says. One of these factors could be sexual selection. Exaggerated physical traits and elaborate behaviors make males of some species more attractive to females but require large amounts of energy and take a toll on overall health.
Perhaps the riskiness of male behavior in humans is built in at the chromosonal level...
henning
OK. How much red meat do you need to eat to have the excessive high iron levels likely to trigger the behavior under consideration in the study? How much higher is the risk?
Also, spinach has iron. So excessive spinach consumption at levels that most people couldn't tolerate could also increase colorectal cancer risk? Or no?
stackghost
Vegans, especially vegan women of menstruating age, are well known to be almost universally iron-deficient, because our bodies absorb iron from meats much more readily than other (such as vegan) sources.
Interestingly, Vitamin C increases the rate at which you can get iron from greens such as spinach. So maybe a glass or orange juice and a bowl of salad a day keeps the doctor away.
david-gpu
If you want vitamin C without the sugar load of drinking orange juice, you may be interested to learn that bell peppers have a much higher content of vitamin C than oranges, either per gram or per calorie.
Edit: Let me offer some USDA data points for those who are curious, but not curious enough to bother Googling for themselves.
Red Bell Peppers: https://fdc.nal.usda.gov/fdc-app.html#/food-details/170108/n...
Green Bell Peppers: https://fdc.nal.usda.gov/fdc-app.html#/food-details/2258588/...
Oranges: https://fdc.nal.usda.gov/fdc-app.html#/food-details/746771/n...
adrian_b
True.
Eating one raw red bell pepper per day is pretty much guaranteed to provide enough vitamin C, even when no other food contains any.
If the red bell peppers are cooked, some of the vitamin C will be lost, but there still should be more than is most kinds of food.
selimthegrim
Even green ones?
aziaziazi
False! probably? :)
Vegetarian resource group 2018 https://www.vrg.org/nutrition/iron.php
> Some might expect that […] vegans might be prone to developing iron deficiency anemia. However, surveys of vegans have found that iron deficiency anemia is no more common among vegetarians than among the general population although vegans tend to have lower iron stores.
> In fact, if the amount of iron in these foods is expressed as milligrams of iron per 100 calories, many foods eaten by vegans are superior to animal-derived foods.[…] you would have to eat more than 1700 calories of sirloin steak to get the same amount of iron as found in 100 calories of spinach.
> Another reason for the satisfactory iron status of vegans is that vegan diets are high in vitamin C
2021 Norway health institute https://pubmed.ncbi.nlm.nih.gov/33803700/
> In conclusion, although the participants were eating a plant-based diet, the majority had sufficient iron status
Nutrients 2021 https://www.mdpi.com/2072-6643/13/9/2964
> We did not find differences in the prevalence of iron deficiency between vegetarians and omnivores among men and women who do not menstruate. Among women who menstruate, vegetarians had a higher prevalence of iron deficiency than omnivores did.
In this last one they’ll mixed non-omnivorous together. Not sure why, and how to calculate it.
adrian_b
It is not this simple.
A vegan diet can provide enough iron, but this is not automatic. One has to actually take care to ensure this.
While some studies like those quoted by you have found vegans who ate enough iron, studies done in other countries have found vegans with iron deficiencies. I have seen at least 2 or 3 such studies, I think one was about vegans in UK.
While there are many vegetables with a relatively high iron content, their iron content is still rather low so you have to eat greater quantities than many people would want to eat. Moreover, many of those vegetables are not cheap and eating large quantities is likely to make the expenses for the daily food greater than when eating food that includes meat.
So yes, vegans can eat enough iron, but they must be aware of the danger of eating too little iron and they must carefully choose their food to avoid this danger. Similar problems are caused by calcium, which exists in vegetables, but also in much smaller amounts than desirable. It is possible to eat a vegan diet with enough iron and calcium, but in many cases it is much less expensive and also easier to eat less food, but complete it with some iron and calcium supplements.
DiscourseFan
Yeah but Vegans consume a lot of vitamin C so that makes a lot of sense.
Also explains why I crave red meat and vitamin C after a workout. Can't get enough of the stuff.
okdood64
Interesting; I have never craved vegetables or fruits after a strength training workout. Only anything high in protein. Eggs, red meat, chicken, whatever.
pessimizer
Spinach doesn't have a lot of iron. The reputation is due to a late-19th century study that was mistaken, and found that spinach had 10x the iron that it actually does.
https://historiesofecology.blogspot.com/2015/08/on-spinach-i...
selimthegrim
“We regret to inform you that the people who were sacked have just been sacked themselves”
https://www5.in.tum.de/~huckle/Sutton_Spinach_Iron_and_Popey...
ygouzerh
That's a good question, spinach have the same type of iron than in red meat, iron-(Fe3+), so it seems that it could a culprit as well.
It looks like however the absorption of iron in red meat is quite high (15%-35%) compared to spinach (2-5%), so maybe not enough to really be a risk factor.
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throw_pm23
Is it the meat or the sodium nitrite used to cure it?
adrian_b
The research paper identifies as the cause of cancer the oxidized Fe(III) ions, which are bound to the hemoglobin from blood or to the myoglobin from red muscles.
Those are the proteins with iron that give to blood the ability to transport oxygen and to red muscles the ability to store oxygen. Similar iron proteins, e.g. the so-called cytochromes, exist in all the cells of all aerobic living beings, but only in amounts many times lower than in the blood and red muscles of vertebrates.
Most of the other iron ions that can be found in water, in food or in iron supplements are reduced Fe(II) ions, which are not involved in this cancer-causing process.
samatman
Headline stripped of bullshit: "Fe(3+) reactivates telomerase of in vitro colorectal cancer cells".
eshack94
It took me way too long to find that (I didn't notice your comment til after).
Sigh at the clickbait headlines.
dh2022
Thank you! This is why I usually read the HN comments before reading the article.
m0llusk
Iron supplements are often used, so it would be interesting to know if they also might be significant risk factors.
adrian_b
The iron supplements normally contain only reduced Fe(II) ions, because only those are soluble in water and easily absorbable in the intestine.
This study identifies only the oxidized Fe(III) ions as causing cancer.
The oxidized Fe(III) ions can have any effect in the intestine only when they are bound to organic molecules, like in blood or in red muscles. Otherwise, the oxidized Fe(III) ions form insoluble precipitates, which either pass through the intestine without any interaction, or they are reduced to soluble Fe(II), which is not harmful, but an essential nutrient.
Nevertheless, an excessively high intake of iron supplements can have various harmful effects, like any other excessive food intake.
smm11
Everything in excess might be a problem. I guess the Standard American Diet is better, right?
otabdeveloper4
We've reached a point where we're starting to literally die out as a species due to obesity and diabetes, and you're complaining about "possibly increased colorectal cancer risk"?
Really?
It pays to be careful with studies like this because even if the statement given is proven to be true, that does not logically imply that it is optimal to reduce red meat consumption.
As a thought experiment (I'm completely making up these claims, but they do at least seem plausible), imagine a world in which regular coffee consumption resulted in some small increase in cancer risk, but then also regular coffee consumption was correlated with say, academic success, success at work, had some appetite suppressing effects, etc.
If the latter outweighs the former then the cancer risk is probably worth it even just longevity wise. Like how we know that going out in the sun increases cancer risk but also is just, well, good for us, to a degree.
But of course the media will just run with a headline, which is why it sometimes feels as if the science is constantly "changing".